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Alternatively, T can be elevated by the more risky use of anabolic steroids (AAS) or testosterone replacement therapy (TRT)to restore the tissue strength required to lift heavier loads and to achieve higher repetitions and repetitions per set (Rosen et al., 2003) or by a low intensity aerobic training intervention to avoid overtraining (Klapmann et al., 2001). In some cases, T administration can be combined with a resistance training intervention to achieve the desired result (Gruber et al., 2007). T also seems to be used in some cases for treatment, prevention or correction of disease states, such as Alzheimer's disease/dementia, heart disease, hypoglycemia, and HIV-1 (Hoffman et al., 1985, 1990; Hirsch et al., 1986; Atherton et al., 2002; Toh et al., 2007; Alonzo et al., 2006). In the context of the present review and review article, there is currently no established use for T in the treatment of muscle soreness, although the use of anti-inflammatory supplements, especially NSAIDs and NSAIDs with anti-inflammatory activity, may be beneficial to patients who experience muscle pain (Bryanton et al., 1996). It is clear however, that T administration for treatment of muscle soreness is not always practical; in particular, the lack of an effective means of managing pain, the use of NSAIDs to treat pain, and the high cost of the latter tend to limit the use of T therapy in routine clinic settings.Although not yet approved by the Food and Drug Administration in the United States, T has recently been approved by the Food and Drug Administration in the United Kingdom for use in the treatment of acute muscle pain (Santiago-Gomez et al., 2008; van Aken et al., 2010). The efficacy of T in this treatment of acute muscle soreness is supported by both human and animal studies (Bryanton et al., 1991; Gruber, 1998; Salvi et al., 2008; Salvi et al., 2011). One of the first human studies assessing the efficacy of T in patients with muscle soreness was a double blind, randomized randomized controlled trial assessing the dose, duration and mode of administration of T in a clinical setting, after acute acute muscle soreness (Muscle Soreness Reduction by T Therapy Study Group, 2007). The results showed that T administered either as 1.2% of total body weight or in two 30 mL infusions over a period of 45 days improved muscle sensitivity to mechanical stimulation after pain was caused by a mechanical stimulus for at least 5 consecutive days, improved muscleSimilar articles: